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We perform universal screening tests for Lynch syndrome (via mismatch repair stains or MSI testing), which can also guide adjuvant therapy for stage II‚III disease. We are beginning to create novel and adaptive clinical trial designs that will allow biomarker enrichment, such as were made in the ToGA trial, which used HER2 to select gastric cancer patients for trial enrollment. With the ability of mass sequencing technologies, we can now characterize individual tumors and the individual patient‚s genome to compare the differences and help determine the driving mutations for tumors.

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