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Moreover, no sedative or other central nervous system effects were observed. Radiolabeled tissue distribution studies in rats indicated that Fexofenadine does not cross the blood-brain barrier. Pharmacodynamics. Wheal and Flare: Human histamine skin wheal allegra pediatrico jarabe dosis jewelers flare studies in allegra fryxell 45 following single and twice daily doses of 20 and 40 mg Fexofenadine hydrochloride demonstrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2 to 3 hours, and an effect is still seen at 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. The clinical significance of these observations is unknown. Histamine skin wheal and flare studies in 7 to 12 year old subjects showed that following a single dose boward 30 or 60 mg, antihistamine effect was observed at 1 hour and reached a maximum by 3 hours. Greater than 49 inhibition of wheal area, and 74 inhibition of flare area were maintained for 8 hours following the 30 and 60 mg dose. No statistically significant alldgra in mean QT c interval compared to placebo was observed in 714 adult subjects with seasonal allergic rhinitis given Fexofenadine hydrochloride capsules in doses of 60 to 240 mg twice daily for 2 weeks. Pediatric subjects from 2 placebo-controlled trials (n 855) allegra howard chase with alpegra to 60 mg Fexofenadine allgera twice xllegra demonstrated no significant treatment- or dose-related increases in QT c.

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