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Additionally, the laws of physics guarantee that in a hand-held firearm the shooter must deal with a backward force equal to the force of the projectile being fired; a gun capable of blowing the target across the room would need to blow the shooter back with even greater force, when you account for the energy the bullet lost due to friction on the way to the target.

Approximately 1,400 tumors will be investigated from patients enrolled in the Alliance N0147 study, which randomized patients to FOLFOX (folinic acid, 5-FU, oxaliplatin) with or without minus cetuximab [13]; the National Surgical Adjuvant Breast and Bowel Project CO7 study, which randomized patients to FOLFOX plus or minus bevacizumab [14]; and an earlier study of 5-FUleucovorin versus FLOX (5-FU, leucovorin [folinic acid], oxaliplatin) [15]. Whole genome sequencing, RNA sequencing, and miRNA analyses will be performed to characterize the role of germline and somatic genetic variability with respect to prognosis, mainly in stage III colorectal cancer. This data set can also be used for pharmacogenomics analysis to study the polymorphisms associated with treatment toxicities. Applying Genomics to Colorectal Cancer Management. Colorectal cancers can be divided into two major pathways, the chromosomal instability pathway (85) and the microsatellite instability pathway (15).

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