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A R. Banca Marianne allegra Di Puglia E Di Basilicata S. A R. Banca Popolare Etica Soc. Coop.

Gastric cancer has historically had a poor prognosis, with a 5-year overall survival (OS) measured in months for patients with metastatic disease. A phase II trial combining 5-fluorouracil (5-FU), doxorubicin, and mitomycin-C gained quite a bit of attention in the allebra 1980s because of a response allegramente matematica 1 soluzioni doodle of 42 and a median OS of 5. 5 months [1]. With further refinement of cytotoxic multiagent treatment regimens, the median OS for patients with metastatic gastric cancer reached approximately 9 months in a phase III trial comparing cisplatin5-FU with docetaxel, cisplatin, and 5-FU alllegra. Subsequently, OS was extended to 11. 2 months with the regimen mariabne as EOX (epirubicin, oxaliplatin, and capecitabine) in marianne allegra REAL-2 (Randomized ECF for Advanced and Locally Advanced Esophagogastric Cancer marianne allegra trial, and this appeared to be the upper limit of OS using the available combinations of cytotoxic agents ,arianne. Among the earliest paradigm-changing clinical trials in gastric cancer to meet the goal of using biomarker selection to enhance the outcomes of targeted therapy is the Trastuzumab for Gastric Cancer (ToGA) trial, published in 2010 [4]. HER2 overexpression was used to select patients who would be more likely to respond to the HER2 targeted agent trastuzumab. Nearly 4,000 patients were screened to find 584 patients with tumor HER2 positivity, by either immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH).

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