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S13 in the Supplementary Appendix). We developed multivariate models to explore the relative contributions of genetic, clinical, and diagnostic variables to overall survival. Using the full model, we could correctly rank approximately 71 of patients for overall survival (vs. 64 with models using only variables in the European LeukemiaNet criteria) ( Figure 3D ). Genomic features were the most powerful predictors, accounting for about two thirds of explained variation, with the other third contributed by demographic, clinical, and treatment variables ( Figure 3D ).

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